Drug interactions
Doxazosin + Lisinopril
Severity: Moderate
Doxazosin and Lisinopril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an alpha-blocker with an ACE inhibitor produces additive blood pressure lowering. Symptomatic hypotension, dizziness or syncope may occur, especially after the first doses or after dose increases.
What this interaction means in plain words
Doxazosin and Lisinopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxazosin belongs to Genitourinary; Lisinopril belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic vasodilation and reduced vascular tone from alpha-1 blockade plus inhibition of the renin-angiotensin system.
What to do
Start the added drug at a low dose, preferably at bedtime, and counsel the patient about orthostatic symptoms. Monitor standing and sitting blood pressure and titrate gradually.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doxazosin
- Alfuzosin + Doxazosin Major
- Amifostine + Doxazosin Major
- Avanafil + Doxazosin Major
- Doxazosin + Dutasteride-tamsulosin Major
- Doxazosin + Phentolamine Major
- Doxazosin + Prazosin Major
Other interactions of Lisinopril
- Aliskiren + Lisinopril Contraindicated
- Lisinopril + Protein a column Contraindicated
- Lisinopril + Sacubitril / valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Lisinopril Major
- Amiloride + Lisinopril Major
Frequently asked questions
Can I take Doxazosin with Lisinopril?
MediHelp rates the interaction as moderate. Doxazosin and Lisinopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining an alpha-blocker with an ACE inhibitor produces additive blood pressure lowering. Symptomatic hypotension, dizziness or syncope may occur, especially after the first doses or after dose increases.
How serious is the interaction between Doxazosin and Lisinopril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start the added drug at a low dose, preferably at bedtime, and counsel the patient about orthostatic symptoms. Monitor standing and sitting blood pressure and titrate gradually.
What other medicines interact with Doxazosin?
MediHelp also lists interactions of Doxazosin with, for example, Alfuzosin, Amifostine, Avanafil. The full list is on the Doxazosin page.
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