Drug interactions
Doxazosin + Moexipril
Severity: Moderate
Doxazosin and Moexipril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxazosin with an ACE inhibitor such as moexipril produces additive blood pressure lowering. Patients may experience symptomatic hypotension, particularly after the first doses or dose increases.
What this interaction means in plain words
Doxazosin and Moexipril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxazosin belongs to Genitourinary; Moexipril belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic vasodilation from alpha-1 blockade and renin-angiotensin system inhibition.
What to do
Introduce the second agent at a low dose, preferably at bedtime, and titrate gradually. Monitor sitting and standing blood pressure and warn the patient about dizziness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doxazosin
- Alfuzosin + Doxazosin Major
- Amifostine + Doxazosin Major
- Avanafil + Doxazosin Major
- Doxazosin + Dutasteride-tamsulosin Major
- Doxazosin + Phentolamine Major
- Doxazosin + Prazosin Major
Other interactions of Moexipril
- Aliskiren + Moexipril Contraindicated
- Moexipril + Protein a column Contraindicated
- Moexipril + Sacubitril / valsartan Contraindicated
- Moexipril + Sacubitril-valsartan Contraindicated
- Amifostine + Moexipril Major
- Amiloride + Moexipril Major
Frequently asked questions
Can I take Doxazosin with Moexipril?
MediHelp rates the interaction as moderate. Doxazosin and Moexipril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Doxazosin with an ACE inhibitor such as moexipril produces additive blood pressure lowering. Patients may experience symptomatic hypotension, particularly after the first doses or dose increases.
How serious is the interaction between Doxazosin and Moexipril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Introduce the second agent at a low dose, preferably at bedtime, and titrate gradually. Monitor sitting and standing blood pressure and warn the patient about dizziness.
What other medicines interact with Doxazosin?
MediHelp also lists interactions of Doxazosin with, for example, Alfuzosin, Amifostine, Avanafil. The full list is on the Doxazosin page.
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