Drug interactions
doxazosin + nifedipine
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Additive vasodilatory effects may cause hypotension, dizziness, and orthostatic symptoms.
Mechanism of action
Pharmacodynamic additive peripheral vasodilation (alpha-1 blockade plus dihydropyridine CCB).
Clinical management
Start low and titrate; monitor seated and standing BP; counsel on orthostatic precautions.
Drug reference
References
- Cardura (doxazosin) Prescribing Information — Warnings: Hypotension with Concomitant Antihypertensives — FDA Label
- Doxazosin: Drug interactions — Lexicomp
Frequently asked questions
Can I take doxazosin with nifedipine?
The interaction is rated: Moderate. Additive vasodilatory effects may cause hypotension, dizziness, and orthostatic symptoms.
How serious is the interaction between doxazosin and nifedipine?
The interaction is rated: Moderate. Evidence level: Moderate.
How is the interaction between doxazosin and nifedipine managed?
Start low and titrate; monitor seated and standing BP; counsel on orthostatic precautions.
Why do doxazosin and nifedipine interact?
Pharmacodynamic additive peripheral vasodilation (alpha-1 blockade plus dihydropyridine CCB).
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