Drug interactions
Doxazosin + Propranolol
Severity: Moderate
Doxazosin and Propranolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propranolol can increase the severity and duration of hypotension seen after the first dose of doxazosin. Syncope and dizziness are the main risks, especially when starting or increasing doses.
What this interaction means in plain words
Doxazosin and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxazosin belongs to Genitourinary; Propranolol belongs to Cardiovascular.
Why it happens
Additive hypotension from alpha-1 adrenergic blockade and nonselective beta blockade.
What to do
Give the first doxazosin dose at bedtime at the lowest strength and titrate slowly. Monitor orthostatic blood pressure and advise caution when standing.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doxazosin
- Alfuzosin + Doxazosin Major
- Amifostine + Doxazosin Major
- Avanafil + Doxazosin Major
- Doxazosin + Dutasteride-tamsulosin Major
- Doxazosin + Phentolamine Major
- Doxazosin + Prazosin Major
Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
- Arformoterol + Propranolol Major
Frequently asked questions
Can I take Doxazosin with Propranolol?
MediHelp rates the interaction as moderate. Doxazosin and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Propranolol can increase the severity and duration of hypotension seen after the first dose of doxazosin. Syncope and dizziness are the main risks, especially when starting or increasing doses.
How serious is the interaction between Doxazosin and Propranolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the first doxazosin dose at bedtime at the lowest strength and titrate slowly. Monitor orthostatic blood pressure and advise caution when standing.
What other medicines interact with Doxazosin?
MediHelp also lists interactions of Doxazosin with, for example, Alfuzosin, Amifostine, Avanafil. The full list is on the Doxazosin page.
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