Drug interactions
Doxazosin + Pseudoephedrine
Severity: Moderate
Doxazosin and Pseudoephedrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pseudoephedrine's alpha-agonist action opposes doxazosin, which may reduce blood pressure control and urinary symptom relief. In men with prostatic enlargement, it may worsen urinary retention.
What this interaction means in plain words
Doxazosin and Pseudoephedrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxazosin belongs to Genitourinary; Pseudoephedrine belongs to Respiratory.
Why it happens
Pharmacodynamic antagonism at alpha-1 adrenoceptors.
What to do
Monitor blood pressure and urinary symptoms; avoid pseudoephedrine in hypertensive patients or those with BPH where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pseudoephedrine
- Isocarboxazid + Pseudoephedrine Contraindicated
- Phenelzine + Pseudoephedrine Contraindicated
- Pseudoephedrine + Rasagiline Contraindicated
- Pseudoephedrine + Selegiline Contraindicated
- Pseudoephedrine + Selegiline transdermal Contraindicated
- Pseudoephedrine + Tranylcypromine Contraindicated
Other interactions of Doxazosin
- Alfuzosin + Doxazosin Major
- Amifostine + Doxazosin Major
- Avanafil + Doxazosin Major
- Doxazosin + Dutasteride-tamsulosin Major
- Doxazosin + Phentolamine Major
- Doxazosin + Prazosin Major
Frequently asked questions
Can I take Doxazosin with Pseudoephedrine?
MediHelp rates the interaction as moderate. Doxazosin and Pseudoephedrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pseudoephedrine's alpha-agonist action opposes doxazosin, which may reduce blood pressure control and urinary symptom relief. In men with prostatic enlargement, it may worsen urinary retention.
How serious is the interaction between Doxazosin and Pseudoephedrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and urinary symptoms; avoid pseudoephedrine in hypertensive patients or those with BPH where possible.
What other medicines interact with Pseudoephedrine?
MediHelp also lists interactions of Pseudoephedrine with, for example, Isocarboxazid, Phenelzine, Rasagiline. The full list is on the Pseudoephedrine page.
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