Drug interactions
Doxazosin + Ramipril
Severity: Moderate
Doxazosin and Ramipril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxazosin with ramipril produces additive blood pressure reduction. Patients may have dizziness or syncope, especially after the first dose or a dose increase.
What this interaction means in plain words
Doxazosin and Ramipril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxazosin belongs to Genitourinary; Ramipril belongs to Cardiovascular.
Why it happens
Additive vasodilation from alpha-1 blockade and inhibition of the renin-angiotensin system.
What to do
Introduce the added drug at a low dose, preferably at bedtime, and titrate gradually. Monitor sitting and standing blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doxazosin
- Alfuzosin + Doxazosin Major
- Amifostine + Doxazosin Major
- Avanafil + Doxazosin Major
- Doxazosin + Dutasteride-tamsulosin Major
- Doxazosin + Phentolamine Major
- Doxazosin + Prazosin Major
Other interactions of Ramipril
- Aliskiren + Ramipril Contraindicated
- Protein a column + Ramipril Contraindicated
- Ramipril + Sacubitril / valsartan Contraindicated
- Ramipril + Sacubitril-valsartan Contraindicated
- Amifostine + Ramipril Major
- Amiloride + Ramipril Major
Frequently asked questions
Can I take Doxazosin with Ramipril?
MediHelp rates the interaction as moderate. Doxazosin and Ramipril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Doxazosin with ramipril produces additive blood pressure reduction. Patients may have dizziness or syncope, especially after the first dose or a dose increase.
How serious is the interaction between Doxazosin and Ramipril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Introduce the added drug at a low dose, preferably at bedtime, and titrate gradually. Monitor sitting and standing blood pressure.
What other medicines interact with Doxazosin?
MediHelp also lists interactions of Doxazosin with, for example, Alfuzosin, Amifostine, Avanafil. The full list is on the Doxazosin page.
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