Drug interactions
Doxazosin + Timolol
Severity: Moderate
Doxazosin and Timolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic absorption of timolol, especially from eye drops in susceptible patients or from oral use, may add to the hypotensive effect of doxazosin. Orthostatic dizziness is the main concern.
What this interaction means in plain words
Doxazosin and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxazosin belongs to Genitourinary; Timolol belongs to Cardiovascular.
Why it happens
Additive hypotension from alpha-1 adrenergic blockade and beta blockade.
What to do
Monitor orthostatic blood pressure and heart rate after starting or changing either drug. Titrate doxazosin gradually.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doxazosin
- Alfuzosin + Doxazosin Major
- Amifostine + Doxazosin Major
- Avanafil + Doxazosin Major
- Doxazosin + Dutasteride-tamsulosin Major
- Doxazosin + Phentolamine Major
- Doxazosin + Prazosin Major
Other interactions of Timolol
- Acebutolol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
- Atenolol-chlorthalidone + Timolol Major
Frequently asked questions
Can I take Doxazosin with Timolol?
MediHelp rates the interaction as moderate. Doxazosin and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic absorption of timolol, especially from eye drops in susceptible patients or from oral use, may add to the hypotensive effect of doxazosin. Orthostatic dizziness is the main concern.
How serious is the interaction between Doxazosin and Timolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor orthostatic blood pressure and heart rate after starting or changing either drug. Titrate doxazosin gradually.
What other medicines interact with Doxazosin?
MediHelp also lists interactions of Doxazosin with, for example, Alfuzosin, Amifostine, Avanafil. The full list is on the Doxazosin page.
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