Drug interactions
Doxercalciferol + Orlistat
Severity: Minor
Doxercalciferol and Orlistat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Orlistat reduces absorption of dietary fat and fat-soluble vitamins, and may similarly reduce absorption of the fat-soluble vitamin D analog doxercalciferol. This could lessen its effect on parathyroid hormone suppression.
What this interaction means in plain words
Doxercalciferol and Orlistat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Orlistat inhibits gastrointestinal lipases and reduces absorption of lipophilic compounds.
What to do
Separate doses by at least 2 hours and monitor intact PTH, calcium and phosphorus.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Orlistat
- Cyclosporin + Orlistat Major
- Orlistat + Triheptanoin Major
- Amiodarone + Orlistat Moderate
- Beta carotene + Orlistat Moderate
- Carbamazepine + Orlistat Moderate
- Cholecalciferol + Orlistat Moderate
Frequently asked questions
Can I take Doxercalciferol with Orlistat?
MediHelp rates the interaction as minor. Doxercalciferol and Orlistat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Orlistat reduces absorption of dietary fat and fat-soluble vitamins, and may similarly reduce absorption of the fat-soluble vitamin D analog doxercalciferol. This could lessen its effect on parathyroid hormone suppression.
How serious is the interaction between Doxercalciferol and Orlistat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate doses by at least 2 hours and monitor intact PTH, calcium and phosphorus.
What other medicines interact with Orlistat?
MediHelp also lists interactions of Orlistat with, for example, Cyclosporin, Triheptanoin, Amiodarone. The full list is on the Orlistat page.
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