Drug interactions
Amiodarone + Orlistat
Severity: Moderate
Amiodarone and Orlistat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Orlistat reduces dietary fat absorption and has been reported to lower absorption of the highly lipophilic amiodarone and its metabolite. Reduced levels could lead to loss of arrhythmia control.
What this interaction means in plain words
Amiodarone and Orlistat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Orlistat belongs to Miscellaneous.
Why it happens
Reduced intestinal absorption of lipophilic amiodarone due to lipase inhibition and reduced fat availability.
What to do
Monitor for recurrent arrhythmia and consider checking amiodarone levels; adjust the dose if needed. Avoid starting orlistat without review if rhythm control is tenuous.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amiodarone and Orlistat, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Orlistat
- Cyclosporine + Orlistat Major
- Cyclosporin + Orlistat Major
- Orlistat + Triheptanoin Major
- Beta carotene + Orlistat Moderate
- Carbamazepine + Orlistat Moderate
- Cholecalciferol + Orlistat Moderate
Frequently asked questions
Can I take Amiodarone with Orlistat?
MediHelp rates the interaction as moderate. Amiodarone and Orlistat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Orlistat reduces dietary fat absorption and has been reported to lower absorption of the highly lipophilic amiodarone and its metabolite. Reduced levels could lead to loss of arrhythmia control.
How serious is the interaction between Amiodarone and Orlistat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for recurrent arrhythmia and consider checking amiodarone levels; adjust the dose if needed. Avoid starting orlistat without review if rhythm control is tenuous.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
