Drug interactions
Doxorubicin + Erdafitinib
Severity: Moderate
Doxorubicin and Erdafitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erdafitinib inhibits P-glycoprotein, which may increase doxorubicin exposure. This could worsen myelosuppression and cardiotoxicity.
What this interaction means in plain words
Doxorubicin and Erdafitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxorubicin belongs to Oncology; Erdafitinib belongs to Oncology.
Why it happens
Erdafitinib inhibits P-gp-mediated efflux of doxorubicin.
What to do
Separate erdafitinib from doxorubicin by at least 6 hours where feasible, and monitor blood counts and cardiac function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doxorubicin
Other interactions of Erdafitinib
Frequently asked questions
Can I take Doxorubicin with Erdafitinib?
MediHelp rates the interaction as moderate. Doxorubicin and Erdafitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erdafitinib inhibits P-glycoprotein, which may increase doxorubicin exposure. This could worsen myelosuppression and cardiotoxicity.
How serious is the interaction between Doxorubicin and Erdafitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate erdafitinib from doxorubicin by at least 6 hours where feasible, and monitor blood counts and cardiac function.
What other medicines interact with Doxorubicin?
MediHelp also lists interactions of Doxorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cobicistat. The full list is on the Doxorubicin page.
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