Drug interactions
Doxorubicin + Etrasimod
Severity: Major
Doxorubicin and Etrasimod: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etrasimod reduces circulating lymphocytes and doxorubicin is myelosuppressive, so combining them may produce additive immunosuppression and a greater risk of infection. The combination has not been formally studied.
What this interaction means in plain words
Doxorubicin and Etrasimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Doxorubicin belongs to Oncology; Etrasimod belongs to Gastrointestinal Tract.
Why it happens
Additive immunosuppression: S1P receptor modulation sequesters lymphocytes while doxorubicin causes myelosuppression.
What to do
Avoid concurrent use where possible and monitor for infection and lymphocyte and neutrophil counts if combined. Allow time for immune recovery after stopping etrasimod.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Doxorubicin
Other interactions of Etrasimod
- Abatacept + Etrasimod Major
- Amiodarone + Etrasimod Major
- Anagrelide + Etrasimod Major
- Anakinra + Etrasimod Major
- Anti-thymocyte + Etrasimod Major
- Asenapine + Etrasimod Major
Frequently asked questions
Can I take Doxorubicin with Etrasimod?
MediHelp rates the interaction as major. Doxorubicin and Etrasimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Etrasimod reduces circulating lymphocytes and doxorubicin is myelosuppressive, so combining them may produce additive immunosuppression and a greater risk of infection. The combination has not been formally studied.
How serious is the interaction between Doxorubicin and Etrasimod?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible and monitor for infection and lymphocyte and neutrophil counts if combined. Allow time for immune recovery after stopping etrasimod.
What other medicines interact with Doxorubicin?
MediHelp also lists interactions of Doxorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cobicistat. The full list is on the Doxorubicin page.
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