Drug interactions
Doxorubicin + Istradefylline
Severity: Moderate
Doxorubicin and Istradefylline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
At 40 mg/day, istradefylline raises exposure to CYP3A4 and P-gp substrates and may increase doxorubicin levels. This could worsen myelosuppression and cardiotoxicity.
What this interaction means in plain words
Doxorubicin and Istradefylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxorubicin belongs to Oncology; Istradefylline belongs to Central Nervous System.
Why it happens
Istradefylline weakly inhibits CYP3A4 and P-gp at higher doses.
What to do
Keep istradefylline at 20 mg/day if possible and monitor blood counts and cardiac status.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doxorubicin
Other interactions of Istradefylline
Frequently asked questions
Can I take Doxorubicin with Istradefylline?
MediHelp rates the interaction as moderate. Doxorubicin and Istradefylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. At 40 mg/day, istradefylline raises exposure to CYP3A4 and P-gp substrates and may increase doxorubicin levels. This could worsen myelosuppression and cardiotoxicity.
How serious is the interaction between Doxorubicin and Istradefylline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Keep istradefylline at 20 mg/day if possible and monitor blood counts and cardiac status.
What other medicines interact with Doxorubicin?
MediHelp also lists interactions of Doxorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cobicistat. The full list is on the Doxorubicin page.
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