Drug interactions
Doxorubicin + Ivosidenib
Severity: Moderate
Doxorubicin and Ivosidenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib induces CYP3A4 and may lower doxorubicin exposure, potentially reducing efficacy. Ivosidenib also prolongs the QT interval, adding a separate cardiac concern.
What this interaction means in plain words
Doxorubicin and Ivosidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxorubicin belongs to Oncology; Ivosidenib belongs to Oncology.
Why it happens
CYP3A4 induction by ivosidenib increases metabolism of doxorubicin, plus additive QT/cardiac risk.
What to do
Monitor ECG and electrolytes and assess treatment response; avoid other QT-prolonging drugs where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doxorubicin
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Doxorubicin with Ivosidenib?
MediHelp rates the interaction as moderate. Doxorubicin and Ivosidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ivosidenib induces CYP3A4 and may lower doxorubicin exposure, potentially reducing efficacy. Ivosidenib also prolongs the QT interval, adding a separate cardiac concern.
How serious is the interaction between Doxorubicin and Ivosidenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes and assess treatment response; avoid other QT-prolonging drugs where possible.
What other medicines interact with Doxorubicin?
MediHelp also lists interactions of Doxorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cobicistat. The full list is on the Doxorubicin page.
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