Drug interactions
Doxorubicin + Larotrectinib
Severity: Minor
Doxorubicin and Larotrectinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Larotrectinib is a CYP3A4 substrate and only a weak inhibitor, so a significant rise in doxorubicin exposure is not expected. No established clinically important interaction exists.
What this interaction means in plain words
Doxorubicin and Larotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Doxorubicin belongs to Oncology; Larotrectinib belongs to Oncology.
Why it happens
Possible weak CYP3A4 inhibition; an effect on doxorubicin is not well established.
What to do
No dose adjustment is needed. Monitor blood counts and cardiac function as for standard doxorubicin therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Doxorubicin
Other interactions of Larotrectinib
Frequently asked questions
Can I take Doxorubicin with Larotrectinib?
MediHelp rates the interaction as minor. Doxorubicin and Larotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Larotrectinib is a CYP3A4 substrate and only a weak inhibitor, so a significant rise in doxorubicin exposure is not expected. No established clinically important interaction exists.
How serious is the interaction between Doxorubicin and Larotrectinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Monitor blood counts and cardiac function as for standard doxorubicin therapy.
What other medicines interact with Doxorubicin?
MediHelp also lists interactions of Doxorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cobicistat. The full list is on the Doxorubicin page.
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