Drug interactions
Doxorubicin + Nelfinavir
Severity: Moderate
Doxorubicin and Nelfinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nelfinavir inhibits CYP3A4 and P-gp and may increase doxorubicin exposure, raising the risk of myelosuppression and cardiotoxicity.
What this interaction means in plain words
Doxorubicin and Nelfinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxorubicin belongs to Oncology; Nelfinavir belongs to Anti Virals.
Why it happens
Inhibition of CYP3A4 and P-gp reduces doxorubicin clearance.
What to do
Monitor blood counts and cardiac function, and consider reducing the doxorubicin dose or switching to an antiretroviral with less enzyme inhibition.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doxorubicin
Other interactions of Nelfinavir
- Alfuzosin + Nelfinavir Contraindicated
- Avanafil + Nelfinavir Contraindicated
- Dronedarone + Nelfinavir Contraindicated
- Eletriptan + Nelfinavir Contraindicated
- Ergotamine + Nelfinavir Contraindicated
- Flibanserin + Nelfinavir Contraindicated
Frequently asked questions
Can I take Doxorubicin with Nelfinavir?
MediHelp rates the interaction as moderate. Doxorubicin and Nelfinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nelfinavir inhibits CYP3A4 and P-gp and may increase doxorubicin exposure, raising the risk of myelosuppression and cardiotoxicity.
How serious is the interaction between Doxorubicin and Nelfinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and cardiac function, and consider reducing the doxorubicin dose or switching to an antiretroviral with less enzyme inhibition.
What other medicines interact with Doxorubicin?
MediHelp also lists interactions of Doxorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cobicistat. The full list is on the Doxorubicin page.
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