Drug interactions
Doxorubicin + Nilotinib
Severity: Moderate
Doxorubicin and Nilotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib inhibits P-glycoprotein and CYP3A4 and may raise doxorubicin exposure. Both drugs can affect the heart, since nilotinib prolongs the QT interval and doxorubicin can cause cardiomyopathy and arrhythmias. Combination may heighten cardiac and hematologic toxicity.
What this interaction means in plain words
Doxorubicin and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxorubicin belongs to Oncology; Nilotinib belongs to Oncology.
Why it happens
Nilotinib inhibits P-glycoprotein efflux, with additive cardiac effects.
What to do
Obtain a baseline ECG and monitor QT, electrolytes (potassium, magnesium) and cardiac function. Monitor blood counts and adjust doxorubicin if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doxorubicin
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Doxorubicin with Nilotinib?
MediHelp rates the interaction as moderate. Doxorubicin and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nilotinib inhibits P-glycoprotein and CYP3A4 and may raise doxorubicin exposure. Both drugs can affect the heart, since nilotinib prolongs the QT interval and doxorubicin can cause cardiomyopathy and arrhythmias. Combination may heighten cardiac and hematologic toxicity.
How serious is the interaction between Doxorubicin and Nilotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor QT, electrolytes (potassium, magnesium) and cardiac function. Monitor blood counts and adjust doxorubicin if toxicity develops.
What other medicines interact with Doxorubicin?
MediHelp also lists interactions of Doxorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cobicistat. The full list is on the Doxorubicin page.
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