Drug interactions
Doxorubicin + Sorafenib
Severity: Moderate
Doxorubicin and Sorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pharmacokinetic studies showed variable and modest changes in doxorubicin exposure when given with sorafenib, with an uncertain mechanism. Both drugs can cause cardiac effects, including hypertension and cardiac ischemia with sorafenib, so overlap in toxicity is possible.
What this interaction means in plain words
Doxorubicin and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxorubicin belongs to Oncology; Sorafenib belongs to Oncology.
Why it happens
Mechanism is not established; possible effects on transporters, with additive cardiovascular toxicity.
What to do
Monitor blood pressure, cardiac function and blood counts during combined therapy. Reduce the dose of either drug if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doxorubicin
Other interactions of Sorafenib
Frequently asked questions
Can I take Doxorubicin with Sorafenib?
MediHelp rates the interaction as moderate. Doxorubicin and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pharmacokinetic studies showed variable and modest changes in doxorubicin exposure when given with sorafenib, with an uncertain mechanism. Both drugs can cause cardiac effects, including hypertension and cardiac ischemia with sorafenib, so overlap in toxicity is possible.
How serious is the interaction between Doxorubicin and Sorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, cardiac function and blood counts during combined therapy. Reduce the dose of either drug if toxicity occurs.
What other medicines interact with Doxorubicin?
MediHelp also lists interactions of Doxorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cobicistat. The full list is on the Doxorubicin page.
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