Drug interactions
Doxorubicin + Sotorasib
Severity: Moderate
Doxorubicin and Sotorasib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotorasib is a P-glycoprotein inhibitor in vitro and clinically raises exposure to P-gp substrates, so doxorubicin levels may increase. The effect on doxorubicin has not been well characterized.
What this interaction means in plain words
Doxorubicin and Sotorasib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxorubicin belongs to Oncology; Sotorasib belongs to Oncology.
Why it happens
Sotorasib inhibits P-gp efflux, which may increase doxorubicin exposure.
What to do
Monitor blood counts and cardiac function and consider doxorubicin dose reduction if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doxorubicin
Other interactions of Sotorasib
- Amobarbital + Sotorasib Major
- Apalutamide + Sotorasib Major
- Carbamazepine + Sotorasib Major
- Colchicine + Sotorasib Major
- Cyclosporin + Sotorasib Major
- Digoxin + Sotorasib Major
Frequently asked questions
Can I take Doxorubicin with Sotorasib?
MediHelp rates the interaction as moderate. Doxorubicin and Sotorasib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sotorasib is a P-glycoprotein inhibitor in vitro and clinically raises exposure to P-gp substrates, so doxorubicin levels may increase. The effect on doxorubicin has not been well characterized.
How serious is the interaction between Doxorubicin and Sotorasib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and cardiac function and consider doxorubicin dose reduction if toxicity develops.
What other medicines interact with Doxorubicin?
MediHelp also lists interactions of Doxorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cobicistat. The full list is on the Doxorubicin page.
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