Drug interactions
Doxorubicin + Stavudine
Severity: Moderate
Doxorubicin and Stavudine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxorubicin may reduce the antiviral activity of stavudine by interfering with its intracellular activation. This could weaken viral suppression during chemotherapy.
What this interaction means in plain words
Doxorubicin and Stavudine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxorubicin belongs to Oncology; Stavudine belongs to Anti Virals.
Why it happens
Doxorubicin inhibits intracellular phosphorylation of stavudine to its active triphosphate.
What to do
Avoid the combination where possible and use an antiretroviral not dependent on phosphorylation. Monitor HIV RNA if both are given.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Doxorubicin and Stavudine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Stavudine
- Didanosine + Stavudine Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Stavudine Contraindicated
- Hydroxycarbamide + Stavudine Contraindicated
- Stavudine + Zidovudine Contraindicated
- Atidarsagene autotemcel + Stavudine Major
- Betibeglogene autotemcel + Stavudine Major
Other interactions of Doxorubicin
Frequently asked questions
Can I take Doxorubicin with Stavudine?
MediHelp rates the interaction as moderate. Doxorubicin and Stavudine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Doxorubicin may reduce the antiviral activity of stavudine by interfering with its intracellular activation. This could weaken viral suppression during chemotherapy.
How serious is the interaction between Doxorubicin and Stavudine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and use an antiretroviral not dependent on phosphorylation. Monitor HIV RNA if both are given.
What other medicines interact with Stavudine?
MediHelp also lists interactions of Stavudine with, for example, Didanosine, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Hydroxycarbamide. The full list is on the Stavudine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
