Drug interactions
Hydroxycarbamide + Stavudine
Severity: Contraindicated
Hydroxycarbamide and Stavudine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydroxycarbamide with stavudine has been linked to fatal and nonfatal pancreatitis, hepatotoxicity and severe peripheral neuropathy. Hepatic failure and lactic acidosis are also of concern.
What this interaction means in plain words
Hydroxycarbamide and Stavudine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Hydroxycarbamide belongs to Oncology; Stavudine belongs to Anti Virals.
Why it happens
Additive mitochondrial and organ toxicity, with hydroxycarbamide possibly increasing stavudine-related toxicity.
What to do
Do not combine; switch to a safer antiretroviral regimen. Monitor liver enzymes, lipase and neuropathy symptoms if exposure has occurred.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Hydroxycarbamide
- Didanosine + Hydroxycarbamide Contraindicated
Other interactions of Stavudine
- Didanosine + Stavudine Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Stavudine Contraindicated
- Stavudine + Zidovudine Contraindicated
- Atidarsagene autotemcel + Stavudine Major
- Betibeglogene autotemcel + Stavudine Major
- Elivaldogene autotemcel + Stavudine Major
Frequently asked questions
Can I take Hydroxycarbamide with Stavudine?
MediHelp rates the interaction as contraindicated. Hydroxycarbamide and Stavudine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Hydroxycarbamide with stavudine has been linked to fatal and nonfatal pancreatitis, hepatotoxicity and severe peripheral neuropathy. Hepatic failure and lactic acidosis are also of concern.
How serious is the interaction between Hydroxycarbamide and Stavudine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; switch to a safer antiretroviral regimen. Monitor liver enzymes, lipase and neuropathy symptoms if exposure has occurred.
What other medicines interact with Hydroxycarbamide?
MediHelp also lists interactions of Hydroxycarbamide with, for example, Didanosine. The full list is on the Hydroxycarbamide page.
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