Drug interactions
Doxorubicin liposomal + Nilotinib
Severity: Moderate
Doxorubicin liposomal and Nilotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib inhibits CYP3A4 and P-gp and may raise doxorubicin exposure, though liposomal encapsulation reduces this. Doxorubicin is cardiotoxic and both agents can affect cardiac function and QT.
What this interaction means in plain words
Doxorubicin liposomal and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of P-gp and CYP3A4 by nilotinib may increase doxorubicin exposure, with overlapping cardiotoxicity.
What to do
Monitor cardiac function, including LVEF, and ECG. Watch for myelosuppression and mucositis.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Doxorubicin liposomal with Nilotinib?
MediHelp rates the interaction as moderate. Doxorubicin liposomal and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nilotinib inhibits CYP3A4 and P-gp and may raise doxorubicin exposure, though liposomal encapsulation reduces this. Doxorubicin is cardiotoxic and both agents can affect cardiac function and QT.
How serious is the interaction between Doxorubicin liposomal and Nilotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cardiac function, including LVEF, and ECG. Watch for myelosuppression and mucositis.
What other medicines interact with Nilotinib?
MediHelp also lists interactions of Nilotinib with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Nilotinib page.
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