Drug interactions
Doxylamine + Fentanyl iontophoretic transdermal system
Severity: Major
Doxylamine and Fentanyl iontophoretic transdermal system: major interaction.
Last updated Sources: Base de donnees publique des medicaments (France)
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fentanyl is a potent opioid, and the iontophoretic system delivers it systemically on demand. Doxylamine adds sedation and may increase the risk of respiratory depression. Opioid labeling warns about concurrent CNS depressants.
What this interaction means in plain words
Doxylamine and Fentanyl iontophoretic transdermal system can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression from opioid agonism and sedating antihistamine effects.
What to do
Avoid concurrent use where possible; otherwise use the lowest effective doses and monitor sedation and respiratory rate. Counsel against alcohol and driving.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Doxylamine
Frequently asked questions
Can I take Doxylamine with Fentanyl iontophoretic transdermal system?
MediHelp rates the interaction as major. Doxylamine and Fentanyl iontophoretic transdermal system can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fentanyl is a potent opioid, and the iontophoretic system delivers it systemically on demand. Doxylamine adds sedation and may increase the risk of respiratory depression. Opioid labeling warns about concurrent CNS depressants.
How serious is the interaction between Doxylamine and Fentanyl iontophoretic transdermal system?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible; otherwise use the lowest effective doses and monitor sedation and respiratory rate. Counsel against alcohol and driving.
What other medicines interact with Doxylamine?
MediHelp also lists interactions of Doxylamine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Doxylamine page.
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