Drug interactions
Doxylamine + Flurazepam
Severity: Moderate
Doxylamine and Flurazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Flurazepam is a long-acting benzodiazepine hypnotic with an active metabolite, and doxylamine is a sedating antihistamine. Together they can cause prolonged sedation, daytime impairment, falls and confusion, especially in older adults.
What this interaction means in plain words
Doxylamine and Flurazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression via GABA-A enhancement and central H1 blockade.
What to do
Avoid combining the two for sleep. If co-use is unavoidable, use minimal doses and monitor for next-day sedation and falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doxylamine
Frequently asked questions
Can I take Doxylamine with Flurazepam?
MediHelp rates the interaction as moderate. Doxylamine and Flurazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Flurazepam is a long-acting benzodiazepine hypnotic with an active metabolite, and doxylamine is a sedating antihistamine. Together they can cause prolonged sedation, daytime impairment, falls and confusion, especially in older adults.
How serious is the interaction between Doxylamine and Flurazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining the two for sleep. If co-use is unavoidable, use minimal doses and monitor for next-day sedation and falls.
What other medicines interact with Doxylamine?
MediHelp also lists interactions of Doxylamine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Doxylamine page.
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