Drug interactions
Doxylamine + Gabapentin
Severity: Moderate
Doxylamine and Gabapentin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxylamine is a strongly sedating antihistamine, and adding it to gabapentin increases drowsiness and psychomotor impairment. Respiratory depression is possible in vulnerable patients.
What this interaction means in plain words
Doxylamine and Gabapentin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxylamine belongs to Respiratory; Gabapentin belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic CNS depression.
What to do
Use the lowest effective doses and advise avoiding alcohol and driving. Monitor for oversedation and respiratory depression, particularly in the elderly or with COPD.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gabapentin
Other interactions of Doxylamine
Frequently asked questions
Can I take Doxylamine with Gabapentin?
MediHelp rates the interaction as moderate. Doxylamine and Gabapentin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Doxylamine is a strongly sedating antihistamine, and adding it to gabapentin increases drowsiness and psychomotor impairment. Respiratory depression is possible in vulnerable patients.
How serious is the interaction between Doxylamine and Gabapentin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and advise avoiding alcohol and driving. Monitor for oversedation and respiratory depression, particularly in the elderly or with COPD.
What other medicines interact with Gabapentin?
MediHelp also lists interactions of Gabapentin with, for example, Alprazolam, Amobarbital, Belladonna and opium. The full list is on the Gabapentin page.
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