Drug interactions
Doxylamine + Lofepramine
Severity: Moderate
Doxylamine and Lofepramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lofepramine is a tricyclic antidepressant with antimuscarinic and mild sedative activity, and doxylamine adds both. The combination can cause drowsiness, dry mouth, constipation, urinary retention and confusion.
What this interaction means in plain words
Doxylamine and Lofepramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive anticholinergic and sedative effects.
What to do
Monitor for oversedation and anticholinergic toxicity, especially in older adults, and avoid routine co-use. Reduce doses or choose a non-sedating alternative if effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doxylamine
Frequently asked questions
Can I take Doxylamine with Lofepramine?
MediHelp rates the interaction as moderate. Doxylamine and Lofepramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lofepramine is a tricyclic antidepressant with antimuscarinic and mild sedative activity, and doxylamine adds both. The combination can cause drowsiness, dry mouth, constipation, urinary retention and confusion.
How serious is the interaction between Doxylamine and Lofepramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and anticholinergic toxicity, especially in older adults, and avoid routine co-use. Reduce doses or choose a non-sedating alternative if effects appear.
What other medicines interact with Doxylamine?
MediHelp also lists interactions of Doxylamine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Doxylamine page.
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