Drug interactions
Doxylamine + Lormetazepam
Severity: Moderate
Doxylamine and Lormetazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lormetazepam is a benzodiazepine hypnotic, and doxylamine is a sedating antihistamine. The combination can cause heavy sedation, impaired psychomotor performance and falls, especially in older adults.
What this interaction means in plain words
Doxylamine and Lormetazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression via GABA-A enhancement and central H1 blockade.
What to do
Avoid combining two sedative hypnotics. If both are used, give the lowest effective doses and monitor for next-day sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doxylamine
Frequently asked questions
Can I take Doxylamine with Lormetazepam?
MediHelp rates the interaction as moderate. Doxylamine and Lormetazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lormetazepam is a benzodiazepine hypnotic, and doxylamine is a sedating antihistamine. The combination can cause heavy sedation, impaired psychomotor performance and falls, especially in older adults.
How serious is the interaction between Doxylamine and Lormetazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining two sedative hypnotics. If both are used, give the lowest effective doses and monitor for next-day sedation.
What other medicines interact with Doxylamine?
MediHelp also lists interactions of Doxylamine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Doxylamine page.
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