Drug interactions
Doxylamine + Meprobamate
Severity: Moderate
Doxylamine and Meprobamate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Meprobamate is a sedative-anxiolytic and doxylamine is a sedating antihistamine. Combined use raises the risk of excessive drowsiness, confusion and impaired coordination, particularly in older adults.
What this interaction means in plain words
Doxylamine and Meprobamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression through GABAergic sedation and central histamine H1 blockade.
What to do
Avoid combining where possible, especially in elderly patients. If both are used, start with lower doses and monitor for oversedation and falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Doxylamine and Meprobamate, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Doxylamine
Frequently asked questions
Can I take Doxylamine with Meprobamate?
MediHelp rates the interaction as moderate. Doxylamine and Meprobamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Meprobamate is a sedative-anxiolytic and doxylamine is a sedating antihistamine. Combined use raises the risk of excessive drowsiness, confusion and impaired coordination, particularly in older adults.
How serious is the interaction between Doxylamine and Meprobamate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible, especially in elderly patients. If both are used, start with lower doses and monitor for oversedation and falls.
What other medicines interact with Doxylamine?
MediHelp also lists interactions of Doxylamine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Doxylamine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
