Drug interactions
Doxylamine + Midazolam intranasal
Severity: Major
Doxylamine and Midazolam intranasal: major interaction.
Last updated Sources: Base de donnees publique des medicaments (France)
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Midazolam produces dose-dependent sedation and respiratory depression, and sedating antihistamines like doxylamine can add to this. The combination can prolong or deepen sedation and increase the risk of hypoventilation.
What this interaction means in plain words
Doxylamine and Midazolam intranasal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression via GABA-A potentiation plus H1 antagonism.
What to do
Avoid concurrent doxylamine where possible and monitor respiratory rate, oxygen saturation and level of sedation after the midazolam dose. Make sure someone can observe the patient and supportive airway care is available.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Doxylamine
Frequently asked questions
Can I take Doxylamine with Midazolam intranasal?
MediHelp rates the interaction as major. Doxylamine and Midazolam intranasal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Midazolam produces dose-dependent sedation and respiratory depression, and sedating antihistamines like doxylamine can add to this. The combination can prolong or deepen sedation and increase the risk of hypoventilation.
How serious is the interaction between Doxylamine and Midazolam intranasal?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent doxylamine where possible and monitor respiratory rate, oxygen saturation and level of sedation after the midazolam dose. Make sure someone can observe the patient and supportive airway care is available.
What other medicines interact with Doxylamine?
MediHelp also lists interactions of Doxylamine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Doxylamine page.
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