Drug interactions
Doxylamine + Triazolam
Severity: Moderate
Doxylamine and Triazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents depress the central nervous system. Together they increase the risk of marked drowsiness, impaired coordination and memory problems, and next-day impairment, particularly in older adults.
What this interaction means in plain words
Doxylamine and Triazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression via H1 antagonism and GABA-A receptor potentiation.
What to do
Avoid concurrent use of two hypnotic-type agents where possible. If used, keep doses low and counsel against driving and other hazardous activities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doxylamine
Frequently asked questions
Can I take Doxylamine with Triazolam?
MediHelp rates the interaction as moderate. Doxylamine and Triazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents depress the central nervous system. Together they increase the risk of marked drowsiness, impaired coordination and memory problems, and next-day impairment, particularly in older adults.
How serious is the interaction between Doxylamine and Triazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of two hypnotic-type agents where possible. If used, keep doses low and counsel against driving and other hazardous activities.
What other medicines interact with Doxylamine?
MediHelp also lists interactions of Doxylamine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Doxylamine page.
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