Drug interactions
Doxylamine + Valerian
Severity: Moderate
Doxylamine and Valerian: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents cause sedation. Combined use may increase drowsiness and psychomotor impairment.
What this interaction means in plain words
Doxylamine and Valerian can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive sedative effects; valerian may act via GABAergic mechanisms and doxylamine via H1 blockade.
What to do
Advise avoiding combined use of sedating products, and counsel about drowsiness and driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doxylamine
Frequently asked questions
Can I take Doxylamine with Valerian?
MediHelp rates the interaction as moderate. Doxylamine and Valerian can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents cause sedation. Combined use may increase drowsiness and psychomotor impairment.
How serious is the interaction between Doxylamine and Valerian?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise avoiding combined use of sedating products, and counsel about drowsiness and driving.
What other medicines interact with Doxylamine?
MediHelp also lists interactions of Doxylamine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Doxylamine page.
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