Drug interactions
Droperidol + Fingolimod
Severity: Major
Droperidol and Fingolimod: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Droperidol carries a boxed warning for QT prolongation and torsades de pointes. Fingolimod causes bradycardia and may contribute to QT effects, so the combination increases the risk of life-threatening arrhythmia.
What this interaction means in plain words
Droperidol and Fingolimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive QTc prolongation, with fingolimod-induced bradycardia increasing arrhythmia susceptibility.
What to do
Avoid droperidol in patients on fingolimod and choose a non-QT-prolonging antiemetic or sedative. If it is unavoidable, obtain an ECG first and monitor continuously.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Droperidol and Fingolimod, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
References
Other interactions of Fingolimod
- Adenovirus types 4 and 7 live + Fingolimod Contraindicated
- Bcg vaccine live + Fingolimod Contraindicated
- Fingolimod + Pimozide Contraindicated
- Fingolimod + Ponesimod Contraindicated
- Fingolimod + Quinidine Contraindicated
- Fingolimod + Siponimod Contraindicated
Frequently asked questions
Can I take Droperidol with Fingolimod?
MediHelp rates the interaction as major. Droperidol and Fingolimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Droperidol carries a boxed warning for QT prolongation and torsades de pointes. Fingolimod causes bradycardia and may contribute to QT effects, so the combination increases the risk of life-threatening arrhythmia.
How serious is the interaction between Droperidol and Fingolimod?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid droperidol in patients on fingolimod and choose a non-QT-prolonging antiemetic or sedative. If it is unavoidable, obtain an ECG first and monitor continuously.
What other medicines interact with Fingolimod?
MediHelp also lists interactions of Fingolimod with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Pimozide. The full list is on the Fingolimod page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
