Drug interactions
Droperidol + Morphine
Severity: Moderate
Droperidol and Morphine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Droperidol is a sedating neuroleptic, and combined with morphine it deepens sedation and may add to hypotension and respiratory depression. Droperidol also prolongs the QT interval, so monitoring is needed in patients with other risk factors.
What this interaction means in plain words
Droperidol and Morphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from dopamine and alpha-adrenergic blockade combined with opioid agonism.
What to do
Use reduced doses and monitor sedation, blood pressure, respiration and ECG in patients with QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Morphine
- Alvimopan + Morphine Contraindicated
- Isocarboxazid + Morphine Contraindicated
- Morphine + Olanzapine / samidorphan Contraindicated
- Morphine + Phenelzine Contraindicated
- Morphine + Tranylcypromine Contraindicated
- Alfentanil + Morphine Major
Frequently asked questions
Can I take Droperidol with Morphine?
MediHelp rates the interaction as moderate. Droperidol and Morphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Droperidol is a sedating neuroleptic, and combined with morphine it deepens sedation and may add to hypotension and respiratory depression. Droperidol also prolongs the QT interval, so monitoring is needed in patients with other risk factors.
How serious is the interaction between Droperidol and Morphine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use reduced doses and monitor sedation, blood pressure, respiration and ECG in patients with QT risk factors.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Morphine page.
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