Drug interactions
Droperidol + Quinine
Severity: Major
Droperidol and Quinine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs prolong the QTc interval and together increase the risk of torsades de pointes. Droperidol carries a boxed warning for QT prolongation.
What this interaction means in plain words
Droperidol and Quinine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive blockade of cardiac potassium channels leading to delayed repolarization.
What to do
Avoid the combination if possible, and use an alternative antiemetic or sedative. If used, obtain an ECG beforehand, correct electrolytes and monitor the rhythm.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Frequently asked questions
Can I take Droperidol with Quinine?
MediHelp rates the interaction as major. Droperidol and Quinine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs prolong the QTc interval and together increase the risk of torsades de pointes. Droperidol carries a boxed warning for QT prolongation.
How serious is the interaction between Droperidol and Quinine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible, and use an alternative antiemetic or sedative. If used, obtain an ECG beforehand, correct electrolytes and monitor the rhythm.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
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