Drug interactions
Droperidol + Scopolamine
Severity: Moderate
Droperidol and Scopolamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Droperidol has some anticholinergic and strong sedative properties, and scopolamine adds antimuscarinic and CNS effects. The combination can increase sedation, confusion and anticholinergic symptoms, and both may be used perioperatively. Droperidol also prolongs the QT interval, and anticholinergic-related tachycardia may be undesirable.
What this interaction means in plain words
Droperidol and Scopolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic and CNS depressant effects.
What to do
Monitor sedation level, mental status and heart rhythm, particularly in older or cardiac patients. Adjust doses downward if excessive sedation or delirium occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Scopolamine
Frequently asked questions
Can I take Droperidol with Scopolamine?
MediHelp rates the interaction as moderate. Droperidol and Scopolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Droperidol has some anticholinergic and strong sedative properties, and scopolamine adds antimuscarinic and CNS effects. The combination can increase sedation, confusion and anticholinergic symptoms, and both may be used perioperatively. Droperidol also prolongs the QT interval, and anticholinergic-related tachycardia may be undesirable.
How serious is the interaction between Droperidol and Scopolamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation level, mental status and heart rhythm, particularly in older or cardiac patients. Adjust doses downward if excessive sedation or delirium occurs.
What other medicines interact with Scopolamine?
MediHelp also lists interactions of Scopolamine with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Scopolamine page.
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