Drug interactions
Droperidol + Sunitinib
Severity: Major
Droperidol and Sunitinib: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Droperidol carries a boxed warning for QT prolongation and torsades de pointes, and sunitinib can also prolong the QT interval. The combination raises the risk of dangerous ventricular arrhythmias.
What this interaction means in plain words
Droperidol and Sunitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive pharmacodynamic prolongation of cardiac repolarization.
What to do
Use a non-QT-prolonging antiemetic such as an alternative agent instead of droperidol. If unavoidable, obtain an ECG beforehand and monitor the rhythm after the dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Sunitinib
- Adagrasib + Sunitinib Major
- Amiodarone + Sunitinib Major
- Amisulpride + Sunitinib Major
- Anagrelide + Sunitinib Major
- Apalutamide + Sunitinib Major
- Arsenic trioxide + Sunitinib Major
Frequently asked questions
Can I take Droperidol with Sunitinib?
MediHelp rates the interaction as major. Droperidol and Sunitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Droperidol carries a boxed warning for QT prolongation and torsades de pointes, and sunitinib can also prolong the QT interval. The combination raises the risk of dangerous ventricular arrhythmias.
How serious is the interaction between Droperidol and Sunitinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a non-QT-prolonging antiemetic such as an alternative agent instead of droperidol. If unavoidable, obtain an ECG beforehand and monitor the rhythm after the dose.
What other medicines interact with Sunitinib?
MediHelp also lists interactions of Sunitinib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sunitinib page.
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