Drug interactions
Drospirenone + Enalapril
Severity: Moderate
Drospirenone and Enalapril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone has antimineralocorticoid activity and can raise serum potassium. Combined with enalapril, which also reduces aldosterone, hyperkalemia is more likely, especially in patients with renal impairment.
What this interaction means in plain words
Drospirenone and Enalapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Drospirenone belongs to Endocrine; Enalapril belongs to Cardiovascular.
Why it happens
Additive potassium retention from drospirenone aldosterone antagonism and ACE inhibition.
What to do
Check serum potassium during the first cycle of use and periodically afterwards. Consider a different contraceptive if potassium rises or renal function is impaired.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enalapril
- Aliskiren + Enalapril Contraindicated
- Enalapril + Protein a column Contraindicated
- Enalapril + Sacubitril / valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Amifostine + Enalapril Major
- Amiloride + Enalapril Major
Other interactions of Drospirenone
Frequently asked questions
Can I take Drospirenone with Enalapril?
MediHelp rates the interaction as moderate. Drospirenone and Enalapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Drospirenone has antimineralocorticoid activity and can raise serum potassium. Combined with enalapril, which also reduces aldosterone, hyperkalemia is more likely, especially in patients with renal impairment.
How serious is the interaction between Drospirenone and Enalapril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium during the first cycle of use and periodically afterwards. Consider a different contraceptive if potassium rises or renal function is impaired.
What other medicines interact with Enalapril?
MediHelp also lists interactions of Enalapril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Enalapril page.
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