Drug interactions
Drospirenone + Erythromycin base
Severity: Minor
Drospirenone and Erythromycin base: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin is a moderate CYP3A4 inhibitor and may modestly raise drospirenone exposure. Drospirenone can raise serum potassium, so the increase matters mainly in patients with renal impairment or those taking other potassium-raising drugs. Clinically significant effects are uncommon in healthy women.
What this interaction means in plain words
Drospirenone and Erythromycin base have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Erythromycin inhibits CYP3A4, reducing drospirenone metabolism.
What to do
No routine adjustment is required; check serum potassium if the patient has renal impairment or takes other potassium-raising drugs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Drospirenone and Erythromycin base, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Drospirenone
Frequently asked questions
Can I take Drospirenone with Erythromycin base?
MediHelp rates the interaction as minor. Drospirenone and Erythromycin base have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Erythromycin is a moderate CYP3A4 inhibitor and may modestly raise drospirenone exposure. Drospirenone can raise serum potassium, so the increase matters mainly in patients with renal impairment or those taking other potassium-raising drugs. Clinically significant effects are uncommon in healthy women.
How serious is the interaction between Drospirenone and Erythromycin base?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is required; check serum potassium if the patient has renal impairment or takes other potassium-raising drugs.
What other medicines interact with Drospirenone?
MediHelp also lists interactions of Drospirenone with, for example, Belzutifan, Bosentan, Carbamazepine. The full list is on the Drospirenone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
