Drug interactions
Drospirenone + Erythromycin ethylsuccinate
Severity: Minor
Drospirenone and Erythromycin ethylsuccinate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin is a moderate CYP3A4 inhibitor and may modestly raise drospirenone exposure. Drospirenone can raise serum potassium, so the increase matters mainly in patients with renal impairment or those taking other potassium-raising drugs. Clinically significant effects are uncommon in healthy women.
What this interaction means in plain words
Drospirenone and Erythromycin ethylsuccinate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Erythromycin inhibits CYP3A4, reducing drospirenone metabolism.
What to do
No routine adjustment is required; check serum potassium if the patient has renal impairment or takes other potassium-raising drugs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Drospirenone
Frequently asked questions
Can I take Drospirenone with Erythromycin ethylsuccinate?
MediHelp rates the interaction as minor. Drospirenone and Erythromycin ethylsuccinate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Erythromycin is a moderate CYP3A4 inhibitor and may modestly raise drospirenone exposure. Drospirenone can raise serum potassium, so the increase matters mainly in patients with renal impairment or those taking other potassium-raising drugs. Clinically significant effects are uncommon in healthy women.
How serious is the interaction between Drospirenone and Erythromycin ethylsuccinate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is required; check serum potassium if the patient has renal impairment or takes other potassium-raising drugs.
What other medicines interact with Drospirenone?
MediHelp also lists interactions of Drospirenone with, for example, Belzutifan, Bosentan, Carbamazepine. The full list is on the Drospirenone page.
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