Drug interactions
Drospirenone + Exenatide
Severity: Minor
Drospirenone and Exenatide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Exenatide slows gastric emptying, which can delay and lower the absorption of oral drugs that depend on rapid uptake, including oral contraceptives. Hormonal contraceptives can also modestly impair glucose tolerance and offset the glucose-lowering effect of exenatide. The clinical effect is usually small but could reduce contraceptive reliability or glycemic control.
What this interaction means in plain words
Drospirenone and Exenatide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Drospirenone belongs to Endocrine; Exenatide belongs to Endocrine.
Why it happens
Exenatide delays gastric emptying and may reduce oral absorption rate, while estrogen/progestin activity can reduce insulin sensitivity.
What to do
Advise patients to take the oral contraceptive at least 1 hour before the exenatide injection and monitor blood glucose. Counsel on backup contraception if vomiting or severe GI effects occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Exenatide
- Chlorpropamide + Exenatide Major
- Asenapine + Exenatide Moderate
- Betamethasone + Exenatide Moderate
- Chlorothiazide + Exenatide Moderate
- Clozapine + Exenatide Moderate
- Cortisone + Exenatide Moderate
Other interactions of Drospirenone
Frequently asked questions
Can I take Drospirenone with Exenatide?
MediHelp rates the interaction as minor. Drospirenone and Exenatide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Exenatide slows gastric emptying, which can delay and lower the absorption of oral drugs that depend on rapid uptake, including oral contraceptives. Hormonal contraceptives can also modestly impair glucose tolerance and offset the glucose-lowering effect of exenatide. The clinical effect is usually small but could reduce contraceptive reliability or glycemic control.
How serious is the interaction between Drospirenone and Exenatide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to take the oral contraceptive at least 1 hour before the exenatide injection and monitor blood glucose. Counsel on backup contraception if vomiting or severe GI effects occur.
What other medicines interact with Exenatide?
MediHelp also lists interactions of Exenatide with, for example, Chlorpropamide, Asenapine, Betamethasone. The full list is on the Exenatide page.
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