Drug interactions
Drospirenone + Fenoprofen
Severity: Moderate
Drospirenone and Fenoprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone has antimineralocorticoid activity and can raise serum potassium, and NSAIDs can also promote potassium retention. Combined chronic use may cause hyperkalemia in predisposed patients, though healthy women rarely have problems.
What this interaction means in plain words
Drospirenone and Fenoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Drospirenone belongs to Endocrine; Fenoprofen belongs to Musculoskeletal.
Why it happens
Drospirenone blocks aldosterone effects while NSAIDs reduce renin-aldosterone activity and renal perfusion, both limiting potassium excretion.
What to do
Check serum potassium during the first cycle in patients on long-term NSAIDs, particularly with renal impairment. Choose a different contraceptive if potassium rises.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Other interactions of Drospirenone
Frequently asked questions
Can I take Drospirenone with Fenoprofen?
MediHelp rates the interaction as moderate. Drospirenone and Fenoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Drospirenone has antimineralocorticoid activity and can raise serum potassium, and NSAIDs can also promote potassium retention. Combined chronic use may cause hyperkalemia in predisposed patients, though healthy women rarely have problems.
How serious is the interaction between Drospirenone and Fenoprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium during the first cycle in patients on long-term NSAIDs, particularly with renal impairment. Choose a different contraceptive if potassium rises.
What other medicines interact with Fenoprofen?
MediHelp also lists interactions of Fenoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Fenoprofen page.
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