Drug interactions
Drospirenone + Hydrochlorothiazide-olmesartan
Severity: Moderate
Drospirenone and Hydrochlorothiazide-olmesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone has antimineralocorticoid activity and can raise potassium, adding to the effect of olmesartan. Hyperkalemia risk is greater with renal impairment, and hydrochlorothiazide only partly offsets it.
What this interaction means in plain words
Drospirenone and Hydrochlorothiazide-olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Drospirenone belongs to Endocrine; Hydrochlorothiazide-olmesartan belongs to Cardiovascular.
Why it happens
Additive reduction in renal potassium excretion through antimineralocorticoid effect and angiotensin receptor blockade.
What to do
Check serum potassium during the first treatment cycle and periodically afterward. Choose another contraceptive in patients with renal impairment or hyperkalemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Other interactions of Drospirenone
Frequently asked questions
Can I take Drospirenone with Hydrochlorothiazide-olmesartan?
MediHelp rates the interaction as moderate. Drospirenone and Hydrochlorothiazide-olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Drospirenone has antimineralocorticoid activity and can raise potassium, adding to the effect of olmesartan. Hyperkalemia risk is greater with renal impairment, and hydrochlorothiazide only partly offsets it.
How serious is the interaction between Drospirenone and Hydrochlorothiazide-olmesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium during the first treatment cycle and periodically afterward. Choose another contraceptive in patients with renal impairment or hyperkalemia.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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