Drug interactions
Drospirenone + Indapamide
Severity: Minor
Drospirenone and Indapamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone has antimineralocorticoid activity and can raise serum potassium, whereas indapamide tends to lower it. Net effect is variable, and hyperkalemia is possible in patients with renal impairment or other potassium-raising drugs.
What this interaction means in plain words
Drospirenone and Indapamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Drospirenone belongs to Endocrine; Indapamide belongs to Cardiovascular.
Why it happens
Drospirenone blocks mineralocorticoid receptors, reducing potassium excretion, opposing indapamide-induced kaliuresis.
What to do
Check serum potassium in the first cycle of combined use in patients at risk, and periodically thereafter.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Drospirenone and Indapamide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Indapamide
Other interactions of Drospirenone
Frequently asked questions
Can I take Drospirenone with Indapamide?
MediHelp rates the interaction as minor. Drospirenone and Indapamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Drospirenone has antimineralocorticoid activity and can raise serum potassium, whereas indapamide tends to lower it. Net effect is variable, and hyperkalemia is possible in patients with renal impairment or other potassium-raising drugs.
How serious is the interaction between Drospirenone and Indapamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium in the first cycle of combined use in patients at risk, and periodically thereafter.
What other medicines interact with Indapamide?
MediHelp also lists interactions of Indapamide with, for example, Adagrasib, Amifostine, Amiodarone. The full list is on the Indapamide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
