Drug interactions
Drospirenone + Indinavir
Severity: Moderate
Drospirenone and Indinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir inhibits CYP3A4 and may raise drospirenone exposure. Drospirenone is not a clinically meaningful CYP3A4 inhibitor, so indinavir levels are not expected to change.
What this interaction means in plain words
Drospirenone and Indinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Indinavir inhibits CYP3A4, reducing the metabolism of drospirenone.
What to do
Check serum potassium during the first cycle in patients with renal or hepatic impairment or other potassium-raising drugs. Consider a non-drospirenone contraceptive if risk factors are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Drospirenone and Indinavir, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Drospirenone
Frequently asked questions
Can I take Drospirenone with Indinavir?
MediHelp rates the interaction as moderate. Drospirenone and Indinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indinavir inhibits CYP3A4 and may raise drospirenone exposure. Drospirenone is not a clinically meaningful CYP3A4 inhibitor, so indinavir levels are not expected to change.
How serious is the interaction between Drospirenone and Indinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium during the first cycle in patients with renal or hepatic impairment or other potassium-raising drugs. Consider a non-drospirenone contraceptive if risk factors are present.
What other medicines interact with Drospirenone?
MediHelp also lists interactions of Drospirenone with, for example, Belzutifan, Bosentan, Carbamazepine. The full list is on the Drospirenone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
