Drug interactions
Drospirenone + Ketorolac
Severity: Moderate
Drospirenone and Ketorolac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone has antimineralocorticoid activity and can raise serum potassium, and NSAIDs may further impair renal potassium excretion. Hyperkalemia is more likely with renal impairment or other potassium-raising drugs.
What this interaction means in plain words
Drospirenone and Ketorolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Drospirenone belongs to Endocrine; Ketorolac belongs to Musculoskeletal.
Why it happens
Additive potassium retention from aldosterone antagonism by drospirenone and NSAID-induced suppression of renin-aldosterone and renal prostaglandins.
What to do
In patients with renal impairment or on other potassium-raising drugs, check serum potassium during the first cycle of concurrent chronic use; ketorolac use should be short-term.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketorolac
- Aceclofenac + Ketorolac Contraindicated
- Acemetacin + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac Contraindicated
- Apixaban + Ketorolac Contraindicated
- Argatroban + Ketorolac Contraindicated
- Aspirin / citric acid / sodium bicarbonate + Ketorolac Contraindicated
Other interactions of Drospirenone
Frequently asked questions
Can I take Drospirenone with Ketorolac?
MediHelp rates the interaction as moderate. Drospirenone and Ketorolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Drospirenone has antimineralocorticoid activity and can raise serum potassium, and NSAIDs may further impair renal potassium excretion. Hyperkalemia is more likely with renal impairment or other potassium-raising drugs.
How serious is the interaction between Drospirenone and Ketorolac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: In patients with renal impairment or on other potassium-raising drugs, check serum potassium during the first cycle of concurrent chronic use; ketorolac use should be short-term.
What other medicines interact with Ketorolac?
MediHelp also lists interactions of Ketorolac with, for example, Aceclofenac, Acemetacin, Acetylsalicylic acid. The full list is on the Ketorolac page.
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