Drug interactions
Drospirenone + Lamotrigine
Severity: Moderate
Drospirenone and Lamotrigine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combined contraceptives containing drospirenone and an estrogen lower lamotrigine levels, risking loss of seizure control. Levels may rise during hormone-free intervals, leading to dose-related adverse effects. Progestin-only drospirenone is expected to have little effect.
What this interaction means in plain words
Drospirenone and Lamotrigine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Drospirenone belongs to Endocrine; Lamotrigine belongs to Central Nervous System.
Why it happens
Estrogen-induced glucuronidation of lamotrigine increases its clearance.
What to do
Monitor clinical response and consider lamotrigine level checks, adjusting the dose when the combined contraceptive is started or stopped. A progestin-only option avoids the interaction.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lamotrigine
Other interactions of Drospirenone
Frequently asked questions
Can I take Drospirenone with Lamotrigine?
MediHelp rates the interaction as moderate. Drospirenone and Lamotrigine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combined contraceptives containing drospirenone and an estrogen lower lamotrigine levels, risking loss of seizure control. Levels may rise during hormone-free intervals, leading to dose-related adverse effects. Progestin-only drospirenone is expected to have little effect.
How serious is the interaction between Drospirenone and Lamotrigine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and consider lamotrigine level checks, adjusting the dose when the combined contraceptive is started or stopped. A progestin-only option avoids the interaction.
What other medicines interact with Lamotrigine?
MediHelp also lists interactions of Lamotrigine with, for example, Desogestrel-ethinyl estradiol, Divalproex, Dofetilide. The full list is on the Lamotrigine page.
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