Drug interactions
Drospirenone + Meclofenamate
Severity: Moderate
Drospirenone and Meclofenamate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone has antimineralocorticoid activity that can raise serum potassium, and NSAIDs such as meclofenamate can impair renal potassium excretion. The combination may add to hyperkalemia risk, especially with renal impairment, diabetes or other potassium-raising drugs.
What this interaction means in plain words
Drospirenone and Meclofenamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hyperkalemia from aldosterone antagonism and NSAID-mediated suppression of prostaglandin-driven renin and renal potassium excretion.
What to do
In at-risk patients, check serum potassium during the first cycle and periodically with long-term NSAID use. Use the lowest effective NSAID dose for the shortest duration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Drospirenone
Frequently asked questions
Can I take Drospirenone with Meclofenamate?
MediHelp rates the interaction as moderate. Drospirenone and Meclofenamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Drospirenone has antimineralocorticoid activity that can raise serum potassium, and NSAIDs such as meclofenamate can impair renal potassium excretion. The combination may add to hyperkalemia risk, especially with renal impairment, diabetes or other potassium-raising drugs.
How serious is the interaction between Drospirenone and Meclofenamate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: In at-risk patients, check serum potassium during the first cycle and periodically with long-term NSAID use. Use the lowest effective NSAID dose for the shortest duration.
What other medicines interact with Drospirenone?
MediHelp also lists interactions of Drospirenone with, for example, Belzutifan, Bosentan, Carbamazepine. The full list is on the Drospirenone page.
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