Drug interactions
Drospirenone + Metformin-sitagliptin
Severity: Minor
Drospirenone and Metformin-sitagliptin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone-containing contraceptives may slightly impair glucose tolerance. Drospirenone also has potassium-sparing activity but this does not directly affect these antidiabetic drugs.
What this interaction means in plain words
Drospirenone and Metformin-sitagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Drospirenone belongs to Endocrine; Metformin-sitagliptin belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism through hormonal effects on insulin sensitivity.
What to do
Monitor glucose after starting the contraceptive. Adjust antidiabetic therapy only if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-sitagliptin
Other interactions of Drospirenone
Frequently asked questions
Can I take Drospirenone with Metformin-sitagliptin?
MediHelp rates the interaction as minor. Drospirenone and Metformin-sitagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Drospirenone-containing contraceptives may slightly impair glucose tolerance. Drospirenone also has potassium-sparing activity but this does not directly affect these antidiabetic drugs.
How serious is the interaction between Drospirenone and Metformin-sitagliptin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose after starting the contraceptive. Adjust antidiabetic therapy only if control worsens.
What other medicines interact with Metformin-sitagliptin?
MediHelp also lists interactions of Metformin-sitagliptin with, for example, Clozapine, Contrast media, Diatrizoate meglumine / diatrizoate. The full list is on the Metformin-sitagliptin page.
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