Drug interactions
Drospirenone + Perindopril
Severity: Moderate
Drospirenone and Perindopril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone is an antimineralocorticoid progestin with potassium-sparing effects, and ACE inhibitors also reduce aldosterone-mediated potassium excretion. Together they can raise serum potassium, particularly in patients with renal impairment.
What this interaction means in plain words
Drospirenone and Perindopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Drospirenone belongs to Endocrine; Perindopril belongs to Cardiovascular.
Why it happens
Additive reduction of aldosterone activity, causing potassium retention.
What to do
Measure serum potassium during the first cycle of combined use and periodically afterward. Avoid in renal impairment or if other potassium-raising drugs are used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Drospirenone and Perindopril, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Perindopril
- Aliskiren + Perindopril Contraindicated
- Perindopril + Protein a column Contraindicated
- Perindopril + Sacubitril / valsartan Contraindicated
- Perindopril + Sacubitril-valsartan Contraindicated
- Amifostine + Perindopril Major
- Amiloride + Perindopril Major
Other interactions of Drospirenone
Frequently asked questions
Can I take Drospirenone with Perindopril?
MediHelp rates the interaction as moderate. Drospirenone and Perindopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Drospirenone is an antimineralocorticoid progestin with potassium-sparing effects, and ACE inhibitors also reduce aldosterone-mediated potassium excretion. Together they can raise serum potassium, particularly in patients with renal impairment.
How serious is the interaction between Drospirenone and Perindopril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Measure serum potassium during the first cycle of combined use and periodically afterward. Avoid in renal impairment or if other potassium-raising drugs are used.
What other medicines interact with Perindopril?
MediHelp also lists interactions of Perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Perindopril page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
