Drug interactions
Drospirenone + Quinapril
Severity: Moderate
Drospirenone and Quinapril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors reduce aldosterone and drospirenone antagonises its receptor, so together they raise hyperkalemia risk. Risk is higher with renal impairment or diabetes.
What this interaction means in plain words
Drospirenone and Quinapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive suppression of aldosterone-mediated potassium excretion.
What to do
Check serum potassium during the first cycle of drospirenone and periodically afterwards. Choose another contraceptive if potassium becomes elevated or renal function is impaired.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Drospirenone
Frequently asked questions
Can I take Drospirenone with Quinapril?
MediHelp rates the interaction as moderate. Drospirenone and Quinapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors reduce aldosterone and drospirenone antagonises its receptor, so together they raise hyperkalemia risk. Risk is higher with renal impairment or diabetes.
How serious is the interaction between Drospirenone and Quinapril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium during the first cycle of drospirenone and periodically afterwards. Choose another contraceptive if potassium becomes elevated or renal function is impaired.
What other medicines interact with Drospirenone?
MediHelp also lists interactions of Drospirenone with, for example, Belzutifan, Bosentan, Carbamazepine. The full list is on the Drospirenone page.
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