Drug interactions
Drospirenone + Somatropin
Severity: Moderate
Drospirenone and Somatropin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral estrogen-containing contraceptives can blunt the IGF-1 response to somatropin. Women taking an estrogen-containing drospirenone product may therefore need a higher growth hormone dose to reach the same effect. Drospirenone alone is not expected to have this effect.
What this interaction means in plain words
Drospirenone and Somatropin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Drospirenone belongs to Endocrine; Somatropin belongs to Endocrine.
Why it happens
Oral estrogen exerts a first-pass hepatic effect that reduces growth hormone-stimulated hepatic IGF-1 production.
What to do
Monitor serum IGF-1 and clinical response, and titrate the somatropin dose accordingly. A non-oral or progestin-only contraceptive can be considered.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Somatropin
- Acarbose + Somatropin Moderate
- Albiglutide + Somatropin Moderate
- Alogliptin-metformin + Somatropin Moderate
- Alogliptin-pioglitazone + Somatropin Moderate
- Alogliptin + Somatropin Moderate
- Betamethasone + Somatropin Moderate
Other interactions of Drospirenone
Frequently asked questions
Can I take Drospirenone with Somatropin?
MediHelp rates the interaction as moderate. Drospirenone and Somatropin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral estrogen-containing contraceptives can blunt the IGF-1 response to somatropin. Women taking an estrogen-containing drospirenone product may therefore need a higher growth hormone dose to reach the same effect. Drospirenone alone is not expected to have this effect.
How serious is the interaction between Drospirenone and Somatropin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum IGF-1 and clinical response, and titrate the somatropin dose accordingly. A non-oral or progestin-only contraceptive can be considered.
What other medicines interact with Somatropin?
MediHelp also lists interactions of Somatropin with, for example, Acarbose, Albiglutide, Alogliptin-metformin. The full list is on the Somatropin page.
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